HIV-associated immune complex glomerulonephritis with “lupus-like” features: A clinicopathologic study of 14 cases11See Editorial by Balow, p. 1632.

A case of immune complex glomerulonephritis associated with pulmonary cryptococcosis.

ACase of Lupus-like Glomerulonephritis in an HIV-infected Patient

Antiretroviral therapy (ART) has increased the life expectancy of human immunodeficiency virus (HIV) infected patients. However, the incidence of kidney diseases in HIV-infected patients has increased. Before the ART era, HIV-associated nephropathy (HIVAN) was the most common type of glomerulonephritis in HIV-related kidney diseases, but after the advent of ART, many other types of glomerulonep...

Clinicopathologic Features of IgA-Dominant Postinfectious Glomerulonephritis

BACKGROUND IgA-dominant acute postinfectious glomerulonephritis (APIGN) is a recently recognized morphologic variant of APIGN, but its clinicopathologic features were not clearly characterized. We will present demographic, clinical and renal biopsy findings from seven patients with IgA-dominant APIGN with a literature review. METHODS All renal biopsy specimens (n=1,119) processed by the Depar...

HIV Associated Lupus Like Nephropathy

BACKGROUND Human immunodeficiency virus type 1 (HIV-1)-seropositive patients are at a high risk for the development of a variety of acute and chronic renal diseases. Most patients with HIVAN are of African descent, presenting late in the course of their HIV-1 infection. The only reliable test to establish or rule out the presence of HIVAN (HIV associated nephropathy) is renal biopsy. The most c...

Toll-like receptor-7 modulates immune complex glomerulonephritis.

Viral infections may trigger immune complex glomerulonephritis via Toll-like receptors (TLR), as certain TLR trigger immunity upon recognition of viral nucleic acids. On the basis of previous findings regarding viral double-stranded RNA and TLR3 in experimental lupus erythematosus, a similar role for TLR7 that recognizes viral single-stranded RNA was hypothesized. Immunostaining of kidney secti...